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Reply To: What is doxyPEP and would I be a candidate?

It is real and it is in the CDC guidance now, from 2024. The short version is a dose of doxycycline taken within 72 hours after sex. The trials showed a large drop in syphilis and chlamydia and a smaller one for gonorrhoea, which fits with how much resistance there already is in gonorrhoea.

It is not offered to everyone. In the US guidance it is aimed at men who have sex with men and transgender women who have had a bacterial STI in the last year, and it is meant to be a conversation with a clinician rather than something you decide alone.

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